Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 5/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.51 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.51 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.49 |
| ▸ | STK3 | Q13188 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7825322 | 1.00 | CHRNA3 (0.53) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7825987 | 0.92 | CHRNB2 (0.62) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7828793 | 0.92 | CHRNB2 (0.62) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7828152 | 0.86 | CHRNA3 (0.58) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7825054 | 0.86 | CHRNA3 (0.58) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7408945 | 0.85 | CHRNA3 (0.49) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7412172 | 0.85 | CHRNA3 (0.49) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7817438 | 0.81 | CHRNA3 (0.56) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7409037 | 0.81 | CHRNA3 (0.56) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7816312 | 0.81 | CHRNA3 (0.56) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | claimed |
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | disclosed |