Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.63 |
| ▸ | RARA | P10276 | 2/20 | 0.51 |
| ▸ | RARB | P10826 | 2/20 | 0.51 |
| ▸ | RARG | P13631 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MYC | P01106 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123466 | 0.93 | MAPK14 (0.72) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL7448719 | 0.92 | MAPK14 (0.57) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL7832639 | 0.90 | RARB (0.56) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL9060705 | 0.88 | MAPK14 (0.51) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL5122607 | 0.83 | MAPK14 (0.60) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL4856436 | 0.83 | MAPK14 (0.67) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL5659598 | 0.83 | MAPK14 (0.67) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL8171164 | 0.83 | RARA (0.54) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL70030 | 0.82 | NPC1 (0.69) | MAPK14RARARARBRARGNPC1 | |
| SCHEMBL6806724 | 0.81 | NPC1 (0.67) | MAPK14RARARARBRARGNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799226-B1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | disclosed |
| US-5972951-A | Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1999-10-26 | — | — | US | disclosed |
| EP-0799226-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019477-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |