Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | MYC | P01106 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829646 | 0.88 | MAPK14 (0.63) | MAPK14MAP2K1NPC1RAB9AKMT2A | |
| SCHEMBL7832639 | 0.87 | RARB (0.56) | MAPK14MAP2K1NPC1RAB9ARARA | |
| SCHEMBL7448719 | 0.85 | MAPK14 (0.57) | MAPK14MAP2K1NPC1RAB9AKMT2A | |
| SCHEMBL16572042 | 0.85 | MYC (0.61) | MAPK14NPC1RAB9AKMT2AMYC | |
| SCHEMBL31658246 | 0.83 | AKR1C3 (0.61) | KMT2ARARBMYCAKR1C3AKR1C2 | |
| SCHEMBL8171164 | 0.82 | RARA (0.54) | MAPK14MAP2K1NPC1RAB9AKMT2A | |
| SCHEMBL5123466 | 0.82 | MAPK14 (0.72) | MAPK14MAP2K1RARARARBRARG | |
| SCHEMBL6252539 | 0.79 | AKR1C3 (0.68) | RARBAKR1C3AKR1C2NR1H4KDM4E | |
| SCHEMBL23752303 | 0.78 | MAPK14 (0.75) | MAPK14MAP2K1NPC1RAB9ALCK | |
| SCHEMBL5659598 | 0.77 | MAPK14 (0.67) | MAPK14MAP2K1NPC1RAB9ARARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996019477-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |