SCHEMBL7829652

SCHEMBL7829652

O=C(c1cccc2ccccc12)N1CC(CO)C(c2ccccc2)C1

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 11/20 0.69
HCRTR1 O43613 1/20 0.46
HCRTR2 O43614 1/20 0.46
AVPR1A P37288 1/20 0.46
ALDH1A1 P00352 2/20 0.45
LMNA P02545 1/20 0.45
CNR1 P21554 1/20 0.45
CNR2 P34972 1/20 0.45
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
HIF1A Q16665 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7863297 0.86 CCR5 (0.54) CCR5HCRTR1HCRTR2AVPR1AALDH1A1
SCHEMBL7839328 0.82 CCR5 (1.00) CCR5
SCHEMBL7817854 0.82 CCR5 (0.68) CCR5
SCHEMBL7829337 0.81 CCR5 (0.76) CCR5MEN1KMT2A
SCHEMBL7817932 0.80 CCR5 (0.57) CCR5HCRTR1HCRTR2AVPR1AALDH1A1
SCHEMBL7829388 0.79 CCR5 (0.79) CCR5
SCHEMBL4099146 0.78 CCR5 (0.48) CCR5
SCHEMBL7833271 0.78 CCR5 (0.89) CCR5
SCHEMBL8090855 0.77 CCR5 (0.75) CCR5
SCHEMBL7882945 0.76 CCR5 (0.46) CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1009405-A4 PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2001-05-09 EP disclosed
US-6166037-A Pyrrolidine and piperidine modulators of chemokine receptor activity MERCK & CO., INC. (US) 2000-12-26 US disclosed
EP-1009405-A1 PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2000-06-21 EP disclosed
WO-1999009984-A1 PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1999-03-04 WO disclosed