Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5900723 | 0.89 | MEN1 (0.57) | MEN1KMT2ALMNAARALDH1A1 | |
| SCHEMBL7817971 | 0.88 | MEN1 (0.57) | MEN1KMT2ALMNAARHSD17B10 | |
| SCHEMBL7402930 | 0.84 | MEN1 (0.53) | MEN1KMT2ALMNAAR | |
| SCHEMBL8188646 | 0.82 | AR (0.51) | MEN1KMT2ALMNAARHSD17B10 | |
| SCHEMBL20488966 | 0.81 | LMNA (0.50) | MEN1KMT2ALMNAARALDH1A1 | |
| SCHEMBL13313003 | 0.76 | LMNA (0.66) | MEN1KMT2ALMNAARHSD17B10 | |
| SCHEMBL4064130 | 0.75 | MEN1 (1.00) | MEN1KMT2ALMNAARSRD5A2 | |
| SCHEMBL4652482 | 0.74 | HCAR2 (0.43) | MEN1KMT2ALMNAAR | |
| SCHEMBL5025427 | 0.74 | ALDH1A1 (0.52) | MEN1KMT2ALMNAARHSD17B10 | |
| SCHEMBL28266776 | 0.73 | AR (0.60) | MEN1KMT2ALMNAARALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066257-A2 | HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | Sugen, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999048868-A2 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN, INC. (US) | 1999-09-30 | — | — | WO | disclosed |