Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874099 | 0.81 | OPRK1 (0.65) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL7468758 | 0.81 | OPRK1 (0.65) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL874098 | 0.81 | OPRK1 (0.65) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL877776 | 0.80 | HDAC6 (0.73) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL8452072 | 0.80 | HDAC6 (0.73) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL876552 | 0.80 | HDAC6 (0.73) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL7822959 | 0.79 | HDAC1 (0.75) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL4287307 | 0.79 | HDAC1 (0.75) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL4289779 | 0.78 | OPRK1 (0.64) | OPRK1HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL873897 | 0.78 | OPRK1 (0.71) | OPRK1HDAC6HDAC1HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655442-B1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5883098-A | USED AS TACHYKININ ANTAGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND INFLAMMATORY DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5670505-A | TACHYKIKIN ANTAGONIST FOR RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| EP-0655442-A1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |