Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830218 | 0.88 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL7829113 | 0.80 | ALDH1A1 (0.93) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL3716740 | 0.80 | ALDH1A1 (0.93) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL3236740 | 0.80 | ALDH1A1 (0.69) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL1021890 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL8383160 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL8383162 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL1449456 | 0.74 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL22426223 | 0.73 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2ASMN1; SMN2MT-CO2 | |
| SCHEMBL911191 | 0.73 | KMT2A (0.51) | ALDH1A1KMT2AUSP2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777653-B1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0777653-A1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006083-A1 | 2-(PIPERAZINYL-1-CARBONYLMETHYL)-1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1996-02-29 | — | — | WO | disclosed |
| WO-1996006082-A1 | DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1996-02-29 | — | — | WO | disclosed |