Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.67 |
| ▸ | DRD4 | P21917 | 7/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824411 | 0.89 | ADRA1A (0.70) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL7816876 | 0.86 | ADRA1A (0.66) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL7817697 | 0.85 | ADRA1A (0.73) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL13809566 | 0.84 | ADRA1A (0.71) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL13809562 | 0.83 | ADRA1A (0.70) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL7824678 | 0.82 | ADRA1A (0.69) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL13809559 | 0.82 | ADRA1A (0.69) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL13809546 | 0.82 | ADRA1A (0.69) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL13809551 | 0.81 | ADRA1A (0.68) | ADRA1ADRD4HTR2ADRD2DRD3 | |
| SCHEMBL13809548 | 0.81 | ADRA1A (0.65) | ADRA1ADRD4HTR2ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732332-A1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | HOECHST MARION ROUSSEL, INC. (US) | 1996-09-18 | — | — | EP | claimed |
| EP-0732332-B1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | AVENTIS PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0732332-A1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | HOECHST MARION ROUSSEL, INC. (US) | 1996-09-18 | — | — | EP | disclosed |