Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203064 | 0.78 | MAPT (0.54) | LTB4RGABRA1GABRB2ALDH1A1MAPT | |
| SCHEMBL5206981 | 0.77 | MAPT (0.51) | LTB4RGABRA1GABRB2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4530760 | 0.74 | PIK3CA (0.48) | PIK3CAPIK3CBPIK3CGALDH1A1SMN1; SMN2 | |
| SCHEMBL17983523 | 0.74 | TYMP (0.60) | GABRA1GABRB2MAPTRAB9ANPC1 | |
| SCHEMBL21373454 | 0.73 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CGALDH1A1MAPT | |
| SCHEMBL2369694 | 0.71 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CGMAPTRAB9A | |
| SCHEMBL4526945 | 0.71 | ROCK1 (0.57) | PIK3CAPIK3CBPIK3CGALDH1A1MAPT | |
| SCHEMBL350869 | 0.70 | TSHR (0.63) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL28712359 | 0.69 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGALDH1A1SMN1; SMN2 | |
| SCHEMBL6385895 | 0.69 | FBP1 (0.50) | GABRA1GABRB2ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |