Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31396449 | 0.81 | PIK3CA (0.45) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL21373454 | 0.76 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL4526945 | 0.74 | ROCK1 (0.57) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL2369694 | 0.74 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL7831016 | 0.74 | LTB4R (0.47) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL28712359 | 0.72 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL4630953 | 0.71 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL5470733 | 0.71 | MEN1 (0.56) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL3133778 | 0.69 | SCN4A (0.55) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL25390143 | 0.69 | RAB9A (0.57) | PIK3CAPIK3CBPIK3CGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | PIK3CA 398/4885PIK3CB 493/4885PIK3CG 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.