Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205170 | 0.84 | MAPT (0.44) | ALDH1A1RAB9AMAPTKDM4EPOLB | |
| SCHEMBL25418348 | 0.82 | SMN1; SMN2 (0.52) | ALDH1A1RAB9AMAPTKDM4EGAA | |
| SCHEMBL28924573 | 0.82 | ALDH1A1 (0.46) | ALDH1A1RAB9AMAPTKDM4EPOLB | |
| SCHEMBL23429368 | 0.77 | CCNB2 (0.53) | ALDH1A1RAB9AMAPTKDM4EPOLB | |
| SCHEMBL7290610 | 0.73 | ALDH1A1 (0.44) | ALDH1A1RAB9AMAPTKDM4EPOLB | |
| SCHEMBL9643682 | 0.72 | MAPT (0.54) | ALDH1A1RAB9AMAPTKDM4EGAA | |
| Carbazole SCHEMBL3924065 | 0.71 | ALDH1A1 (0.58) | ALDH1A1RAB9AMAPTKDM4EGAA | |
| SCHEMBL6982959 | 0.71 | HTR2A (0.62) | ALDH1A1MAPTKDM4EPOLBGAA | |
| SCHEMBL3656418 | 0.71 | HTR2A (0.62) | ALDH1A1MAPTKDM4EPOLBGAA | |
| SCHEMBL9457713 | 0.71 | KDM4E (0.53) | ALDH1A1MAPTKDM4EPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265586-B1 | REACTING (5S)-2-AMINO-5-((1R)-1-(INDOL-3-YL)ETHYL)-4-OXAZOLONE WITH METHYLAMINE OR ITS SALT TO FOMRMING INDOLMYCIN | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-1068201-A1 | PROCESS FOR PRODUCING INDOLMYCINS | Takeda Chemical Industries, Ltd. (JP) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999052905-A1 | PROCESS FOR PRODUCING INDOLMYCINS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-21 | — | — | WO | disclosed |