Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.63 |
| ▸ | ITGAV | P06756 | 20/20 | 0.63 |
| ▸ | ITGB6 | P18564 | 14/20 | 0.63 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.55 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.55 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.55 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.55 |
| ▸ | ITGA8 | P53708 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778120 | 0.92 | ITGB3 (0.54) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7832530 | 0.92 | ITGB3 (0.64) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6777304 | 0.92 | ITGB3 (0.64) | ITGB3ITGAVITGB6 | |
| SCHEMBL7837890 | 0.89 | ITGB3 (0.56) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6778582 | 0.89 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6774644 | 0.87 | ITGB3 (0.64) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL612700 | 0.87 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7338411 | 0.85 | ITGB3 (0.54) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7340807 | 0.84 | ITGB3 (0.63) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7341209 | 0.84 | GPR139 (0.52) | ITGB3ITGAVITGB6ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |