Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821710 | 0.86 | SMN1; SMN2 (0.47) | POLBLMNAHTTSMN1; SMN2TP53 | |
| SCHEMBL7832968 | 0.80 | HPGD (0.47) | POLBSMN1; SMN2TRPC5 | |
| SCHEMBL7830570 | 0.78 | TRPC5 (0.42) | HTTCHRM1ALDH1A1TRPC5 | |
| SCHEMBL7836731 | 0.76 | MAPT (0.46) | POLBLMNAMAPTSMN1; SMN2TP53 | |
| SCHEMBL7831207 | 0.75 | GRIN1 (0.41) | TNFTRPC5 | |
| SCHEMBL7833670 | 0.75 | TRPC5 (0.40) | POLBLMNAMAPTALDH1A1TRPC5 | |
| SCHEMBL7830433 | 0.75 | KDM4E (0.45) | MAPTCHRM1ALDH1A1PKMGAA | |
| SCHEMBL7834547 | 0.75 | TSHR (0.44) | POLBLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL7833731 | 0.75 | PDE4A (0.41) | POLBLMNAMAPTTP53ALDH1A1 | |
| SCHEMBL7832934 | 0.74 | TRPC5 (0.35) | TNFALDH1A1TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |