Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.35 |
| ▸ | PDE4A | P27815 | 6/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835528 | 0.80 | DGAT1 (0.37) | TRPC5ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7834052 | 0.79 | PDE4A (0.40) | TRPC5ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7836731 | 0.79 | MAPT (0.46) | TRPC5ALDH1A1MEN1KMT2A | |
| SCHEMBL7832968 | 0.77 | HPGD (0.47) | TRPC5ADORA2BMEN1KMT2ABRD4 | |
| SCHEMBL8026931 | 0.77 | ALDH1A1 (0.51) | ALDH1A1ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7821710 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7821875 | 0.75 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL7830570 | 0.75 | TRPC5 (0.42) | TRPC5ALDH1A1MEN1KMT2ABRD4 | |
| SCHEMBL7832039 | 0.74 | TNF (0.40) | TRPC5ALDH1A1TNF | |
| SCHEMBL7834547 | 0.72 | TSHR (0.44) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |