Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30767099 | 1.00 | NOTUM (0.59) | NOTUMKDM4ELMNANPSR1HPGD | |
| SCHEMBL7830913 | 0.90 | CNR2 (0.47) | NOTUMKDM4ENPSR1HPGDALDH1A1 | |
| SCHEMBL6752845 | 0.85 | NOTUM (0.59) | NOTUMKDM4ELMNAHSD17B10MAPT | |
| SCHEMBL8523193 | 0.85 | NOTUM (0.53) | NOTUMKDM4ELMNAALDH1A1POLB | |
| SCHEMBL3653813 | 0.85 | NOTUM (0.61) | NOTUMKDM4ELMNANPSR1ALDH1A1 | |
| SCHEMBL7832103 | 0.84 | NOTUM (0.57) | NOTUMKDM4ELMNAHPGDALDH1A1 | |
| SCHEMBL30211951 | 0.84 | NOTUM (0.57) | NOTUMKDM4ELMNAHPGDALDH1A1 | |
| SCHEMBL24011079 | 0.83 | NOTUM (0.84) | NOTUMLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7669258 | 0.81 | NOTUM (0.57) | NOTUMKDM4ELMNAHSD17B10MAPT | |
| SCHEMBL7552151 | 0.81 | NOTUM (0.63) | NOTUMKDM4ELMNANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076977-A1 | METHODS FOR TREATMENT OF DISEASES | GALERA LABS LLC (US) | 2026-03-19 | — | — | US | disclosed |
| US-20250017944-A1 | METHODS FOR TREATMENT OF DISEASES | GALERA LABS, LLC | 2025-01-16 | — | — | US | disclosed |
| CN-117529319-A | Orbicifrapib for the treatment of dementia | 新阿姆斯特丹制药私人有限公司 | 2024-02-06 | — | — | CN | disclosed |
| EP-1670765-A2 | CETP INHIBITORS AND METABOLITES THEREOF | Pfizer Products Inc. (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005033082-A2 | CETP INHIBITORS AND METABOLITES THEREOF | PFIZER PRODUCTS INC. (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250017944-A1 | METHODS FOR TREATMENT OF DISEASES | SOD1, GLS, GLS2 | NOTUM 4155/4885KDM4E 4387/4885LMNA 1540/4885 |
| US-20260076977-A1 | METHODS FOR TREATMENT OF DISEASES | SOD1, SOD3, CAT | NOTUM 3711/4885KDM4E 2325/4885LMNA 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.