Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.58 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16048953 | 0.86 | KDM4E (0.66) | CYP11B2CYP11B1KDM4EALDH1A1HPGD | |
| SCHEMBL16047508 | 0.85 | KCNA5 (0.62) | CYP19A1KDM4EALDH1A1HPGDKCNA5 | |
| SCHEMBL11620358 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL5749914 | 0.79 | CYP11B2 (0.50) | CYP11B2CYP11B1CYP17A1CYP19A1KDM4E | |
| SCHEMBL8318119 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1HPGDRAB9AMEN1 | |
| SCHEMBL31536244 | 0.75 | CYP11B2 (0.55) | CYP11B2CYP11B1CYP17A1CYP19A1KDM4E | |
| SCHEMBL4114679 | 0.74 | SYK (0.56) | ALDH1A1RAB9ANPC1 | |
| SCHEMBL6338303 | 0.73 | CYP17A1 (0.57) | CYP11B2CYP11B1CYP17A1CYP19A1TEK | |
| SCHEMBL17084671 | 0.73 | ALDH1A1 (0.59) | CYP11B2CYP11B1KDM4EALDH1A1HPGD | |
| SCHEMBL16046684 | 0.73 | KDM4E (0.59) | KDM4EALDH1A1HPGDRAB9AKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073640-A1 | NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054309-A1 | NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-28 | — | — | WO | disclosed |