Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGAV | P06756 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.42 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.42 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824024 | 0.94 | GPR139 (0.49) | NAMPTMAPTTHRBGPR139MEN1 | |
| SCHEMBL7833918 | 0.93 | NAMPT (0.56) | NAMPTKMT2AITGB3ITGAVITGB1 | |
| SCHEMBL6773780 | 0.93 | NAMPT (0.49) | NAMPTMAPTTHRBGPR139ITGB3 | |
| SCHEMBL6778847 | 0.89 | ITGB3 (0.53) | GPR139MEN1KMT2AATMITGB3 | |
| SCHEMBL6779485 | 0.87 | NAMPT (0.50) | NAMPTMAPTTHRBKMT2AITGB3 | |
| SCHEMBL7340505 | 0.86 | NAMPT (0.46) | NAMPTMAPTMEN1KMT2AITGB3 | |
| SCHEMBL7366148 | 0.85 | TSHR (0.41) | NAMPTMAPTGPR139KMT2AITGB3 | |
| SCHEMBL7339953 | 0.85 | NAMPT (0.46) | NAMPTMAPTTHRBGPR139MEN1 | |
| SCHEMBL6778762 | 0.85 | ITGB3 (0.51) | NAMPTMAPTMEN1KMT2AITGB3 | |
| SCHEMBL7832444 | 0.84 | NAMPT (0.48) | NAMPTMAPTTHRBGPR139MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |