Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 8/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 5/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | GSK3A | P49840 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | CDK7 | P50613 | 2/20 | 0.59 |
| ▸ | CDK9 | P50750 | 2/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828051 | 0.84 | TLK2 (0.72) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL8185332 | 0.83 | TLK2 (0.68) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL29476105 | 0.79 | TLK2 (1.00) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL12722125 | 0.77 | TLK2 (0.67) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL7834368 | 0.77 | PDGFRB (1.00) | MAPTSMN1; SMN2KDRPDGFRBFGFR1 | |
| SCHEMBL7834370 | 0.77 | PDGFRB (1.00) | MAPTSMN1; SMN2KDRPDGFRBFGFR1 | |
| SCHEMBL8192156 | 0.77 | KDR (0.59) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| SCHEMBL14521208 | 0.76 | NPC1 (0.62) | MAPTSMN1; SMN2KDRPDGFRBFGFR1 | |
| Su-9516 SCHEMBL1170686 | 0.74 | TLK2 (1.00) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 | |
| Su-9516 SCHEMBL1170687 | 0.74 | TLK2 (1.00) | TLK2CDK5MAPTCDK5R1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066257-A2 | HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | Sugen, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048868-A2 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN, INC. (US) | 1999-09-30 | — | — | WO | disclosed |