Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 1.00 |
| ▸ | KDR | P35968 | 11/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 9/20 | 1.00 |
| ▸ | SRC | P12931 | 8/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | YES1 | P07947 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834370 | 1.00 | PDGFRB (1.00) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL7838947 | 0.84 | FGFR1 (1.00) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL7838948 | 0.84 | FGFR1 (1.00) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL7825508 | 0.82 | PDGFRB (0.72) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL8211103 | 0.82 | PDGFRB (0.72) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL1063000 | 0.82 | KDR (1.00) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL1062998 | 0.82 | KDR (1.00) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL14519098 | 0.82 | KDR (1.00) | PDGFRBKDRFGFR1SRCCHEK1 | |
| SCHEMBL3487517 | 0.77 | KDR (0.85) | PDGFRBKDRFGFR1SRCRET | |
| SCHEMBL7832595 | 0.77 | TLK2 (0.67) | PDGFRBKDRFGFR1SRCCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066257-A2 | HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | Sugen, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999048868-A2 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN, INC. (US) | 1999-09-30 | — | — | WO | disclosed |