Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | ESRRA | P11474 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24590310 | 0.84 | GPR84 (0.43) | GPR84ALDH1A1IMPDH2CA2HTR2A | |
| SCHEMBL7009806 | 0.82 | POLB (0.42) | GPR84ALDH1A1IMPDH2HTR2AHTR6 | |
| SCHEMBL8171204 | 0.82 | GPR84 (0.38) | GPR84ALDH1A1IMPDH2CA2HTT | |
| SCHEMBL19386185 | 0.79 | HTR2A (0.58) | HTR2AHTR6HTR7 | |
| SCHEMBL6269717 | 0.79 | HTR2A (0.39) | GPR84ALDH1A1IMPDH2HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9823287 | 0.78 | HTR2A (0.57) | ALDH1A1HTTHTR2AHTR6 | |
| SCHEMBL24590236 | 0.78 | GPR84 (0.39) | GPR84ALDH1A1IMPDH2CA2HTT | |
| SCHEMBL27501032 | 0.77 | OXER1 (0.46) | ALDH1A1HTR2AHTR6HTR7RORC | |
| SCHEMBL10676153 | 0.76 | MCL1 (0.38) | GPR84ALDH1A1HTTSMN1; SMN2HTR2A | |
| SCHEMBL24877812 | 0.76 | HTR6 (0.59) | HTR6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | claimed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | claimed |
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | disclosed |