Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.43 |
| ▸ | ITGAV | P06756 | 6/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.43 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.43 |
| ▸ | ITGB8 | P26012 | 6/20 | 0.43 |
| ▸ | ITGA8 | P53708 | 6/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | ATF1 | P18846 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838264 | 0.91 | ITGB3 (0.51) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL6778978 | 0.87 | ITGB3 (0.55) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7346866 | 0.84 | GPR139 (0.41) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL16918573 | 0.82 | ITGB3 (0.39) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7823466 | 0.82 | GPR139 (0.40) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7339440 | 0.81 | GPR139 (0.41) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL6777228 | 0.81 | ITGB3 (0.53) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL6773907 | 0.81 | ITGB3 (0.53) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7341726 | 0.79 | GPR139 (0.42) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL16918488 | 0.78 | ITGB3 (0.45) | ITGB3ITGB1ITGAVITGA5ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |