SCHEMBL7833192

SCHEMBL7833192

Cc1cccc(C)c1SCc1nc2cc(-n3ccnc3)ccc2[nH]1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F9 P00740 1/20 0.44
CBFB Q13951 1/20 0.40
CYP11B1 P15538 2/20 0.40
CYP11B2 P19099 2/20 0.40
CYP19A1 P11511 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.39
ALDH1A1 P00352 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
HPGD P15428 1/20 0.38
GAA P10253 2/20 0.37
FGFR1 P11362 1/20 0.37
FLT1 P17948 1/20 0.37
MEN1 O00255 1/20 0.37
THRB P10828 1/20 0.37
KMT2A Q03164 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MAOA P21397 2/20 0.37
MAOB P27338 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7830596 0.99 F9 (0.44) F9CBFBCYP11B1CYP11B2CYP19A1
SCHEMBL7833198 0.92 CBFB (0.49) F9CBFBCYP11B1CYP11B2CYP19A1
SCHEMBL7821973 0.91 MAOA (0.43) F9CBFBCYP11B1CYP11B2CYP19A1
Hydrochloric Acid SCHEMBL7830602 0.91 CBFB (0.48) F9CBFBCYP11B1CYP11B2CYP19A1
SCHEMBL7833717 0.87 F9 (0.41) F9CBFBCYP11B1CYP11B2CYP19A1
SCHEMBL7840878 0.87 MAOA (0.45) F9CBFBCYP11B1CYP11B2CYP19A1
SCHEMBL7833472 0.85 CBFB (0.39) F9CBFBCYP11B1CYP11B2CYP19A1
SCHEMBL7821986 0.84 NPC1 (0.55) F9CBFBCYP11B1CYP11B2CYP19A1
SCHEMBL7821975 0.83 MAOA (0.45) F9CBFBCYP11B1CYP11B2CYP19A1
Hydrochloric Acid SCHEMBL8155587 0.83 NPC1 (0.54) F9CBFBCYP11B1CYP11B2CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0894795-B1 Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them ADIR (FR) 2001-06-06 EP claimed
EP-0894795-A1 Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1999-02-03 EP claimed
EP-0894795-B1 Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them ADIR (FR) 2001-06-06 EP disclosed
EP-0894795-A1 Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1999-02-03 EP disclosed