Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8155587 | 0.99 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL7821991 | 0.91 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL8155594 | 0.90 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL7832389 | 0.89 | ENPP2 (0.47) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL7834574 | 0.86 | CYP11B1 (0.51) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL7833717 | 0.84 | F9 (0.41) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL7833192 | 0.84 | F9 (0.44) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7822232 | 0.83 | TNIK (0.45) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL7830596 | 0.83 | F9 (0.44) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7833322 | 0.82 | MAOA (0.49) | NPC1RAB9ASMN1; SMN2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894795-B1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-06 | — | — | EP | claimed |
| US-6040327-A | INHIBITORS OF INTERLEUKINS; TREATING RHEUMATOID ARTHRITIS OR ARTHROSIS | ADIR ET COMPAGNIE (FR) | 2000-03-21 | — | — | US | claimed |
| EP-0894795-A1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | claimed |
| EP-0894795-B1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| EP-0894795-A1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |