Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701556 | 0.84 | ALDH1A1 (0.65) | ALDH1A1TDP1AURKAGSK3AGSK3B | |
| SCHEMBL11757662 | 0.81 | ALDH1A1 (0.57) | ALDH1A1TDP1NPC1RAB9AFAAH | |
| SCHEMBL29050942 | 0.79 | ALDH1A1 (0.54) | ALDH1A1TDP1AURKAGSK3AGSK3B | |
| SCHEMBL7785924 | 0.79 | ALDH1A1 (0.67) | ALDH1A1TDP1AURKAGSK3AGSK3B | |
| SCHEMBL4988037 | 0.78 | ALDH1A1 (0.56) | ALDH1A1TDP1AURKAGSK3AGSK3B | |
| SCHEMBL3956866 | 0.78 | ALDH1A1 (0.65) | ALDH1A1TDP1AURKAGSK3AGSK3B | |
| SCHEMBL32679855 | 0.78 | ALDH1A1 (0.70) | ALDH1A1TDP1AURKAGSK3AGSK3B | |
| SCHEMBL17468329 | 0.78 | ALDH1A1 (0.65) | ALDH1A1TDP1AURKAGSK3AGSK3B | |
| SCHEMBL10712973 | 0.75 | ALDH1A1 (0.71) | ALDH1A1TDP1TSHRMEN1GAA | |
| SCHEMBL27964024 | 0.75 | ALDH1A1 (0.58) | ALDH1A1KAT2BRAB9ASIGMAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140876-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035891-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |