Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 2/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785924 | 0.84 | ALDH1A1 (0.67) | ALDH1A1TDP1GSK3AGSK3BAURKA | |
| SCHEMBL7833436 | 0.84 | ALDH1A1 (0.57) | ALDH1A1TDP1GSK3AGSK3BAURKA | |
| SCHEMBL3956866 | 0.83 | ALDH1A1 (0.65) | ALDH1A1TDP1GSK3AGSK3BAURKA | |
| SCHEMBL17468329 | 0.83 | ALDH1A1 (0.65) | ALDH1A1TDP1GSK3AGSK3BAURKA | |
| SCHEMBL32679855 | 0.83 | ALDH1A1 (0.70) | ALDH1A1TDP1GSK3AGSK3BAURKA | |
| SCHEMBL10712973 | 0.80 | ALDH1A1 (0.71) | ALDH1A1TDP1S100A4PTPRCTSHR | |
| SCHEMBL98895 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TDP1LOXL2TAAR1TSHR | |
| SCHEMBL2958562 | 0.80 | ALDH1A1 (0.92) | ALDH1A1TDP1S100A4PTPRCTSHR | |
| Benzylamine SCHEMBL27935314 | 0.80 | LOXL2 (0.58) | ALDH1A1TDP1LOXL2TSHRGAA | |
| SCHEMBL30196067 | 0.79 | ALDH1A1 (1.00) | ALDH1A1TDP1S100A4PTPRCTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726319-A | Biphenyl substituted dipeptide analogs promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | disclosed |
| EP-0669830-A4 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1997-02-26 | — | — | EP | disclosed |
| EP-0669830-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5330989-A | Heterocycles substituted with biphenyl-3-cyclobutene-1,2-dione derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-07-19 | — | — | US | disclosed |
| WO-1994011012-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-05-26 | — | — | WO | disclosed |