Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.32 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3096203 | 0.89 | HSD17B10 (0.50) | RAB9ANPC1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL3085757 | 0.85 | HSD17B10 (0.49) | RAB9ANPC1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL3087049 | 0.81 | HSD17B10 (0.59) | RAB9ANPC1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL7543844 | 0.80 | NTRK1 (0.47) | RAB9ANPC1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL7831508 | 0.78 | HAO1 (0.40) | RAB9ANPC1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL3078202 | 0.77 | NTRK1 (0.44) | HSD17B10HTTNTRK1 | |
| SCHEMBL3090202 | 0.77 | HSD17B10 (0.44) | HSD17B10HTTNTRK1 | |
| SCHEMBL3083495 | 0.76 | HSD17B10 (0.41) | HSD17B10HTTNTRK1 | |
| SCHEMBL3073813 | 0.76 | ALDH1A1 (0.43) | RAB9ANPC1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL7827786 | 0.75 | HAO1 (0.40) | RAB9ANPC1SMN1; SMN2POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |