Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Vapiprost. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 19/20 | 0.96 |
| ▸ | MEN1 | O00255 | 1/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.96 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vapiprost SCHEMBL9344105 | 0.98 | TBXA2R (1.00) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL8895507 | 0.98 | TBXA2R (1.00) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL9342604 | 0.98 | TBXA2R (1.00) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL28551 | 0.98 | TBXA2R (1.00) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL28550 | 0.98 | TBXA2R (1.00) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL9342608 | 0.98 | TBXA2R (1.00) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL635147 | 0.97 | TBXA2R (0.98) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL635146 | 0.97 | TBXA2R (0.98) | TBXA2RMEN1KMT2ATBXAS1 | |
| Vapiprost SCHEMBL27984405 | 0.97 | TBXA2R (0.98) | TBXA2RMEN1KMT2ATBXAS1 | |
| SCHEMBL10489337 | 0.93 | TBXA2R (0.90) | TBXA2RMEN1KMT2ATBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667347-B1 | Beta-carboline thromboxane synthase inhibitors | LILLY CO ELI (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0668279-B1 | 6-Azaindole thromboxane synthase inhibitors | LILLY CO ELI (US) | 2001-06-13 | — | — | EP | disclosed |
| US-5604236-A | PYRIDO(3,4-B)INDOLES AS ENZYME INHIBITOR, POTENT THAN ASPIRIN | ELI LILLY AND COMPANY (US) | 1997-02-18 | — | — | US | disclosed |
| US-5550118-A | THROMBOXANE SYNTHETASE INHIBITORS, ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1996-08-27 | — | — | US | disclosed |
| US-5468757-A | FOR TREATING STROKE OR MYOCARDIAL INFARCTION IN HUMANS | ELI LILLY AND COMPANY (US) | 1995-11-21 | — | — | US | disclosed |
| EP-0668279-A2 | 6-Azaindole thromboxane synthase inhibitors | ELI LILLY AND COMPANY (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0667347-A1 | Beta-carboline thromboxane synthase inhibitors | ELI LILLY AND COMPANY (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0665227-A1 | Polyhydronorharman synthase inhibitors | ELI LILLY AND COMPANY (US) | 1995-08-02 | — | — | EP | disclosed |