Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19111000 | 0.81 | LMNA (0.58) | LMNAHTTMAPK1GAATDP1 | |
| SCHEMBL19116549 | 0.81 | SMN1; SMN2 (0.49) | LMNAHTTSMN1; SMN2ADORA1PTPN1 | |
| SCHEMBL19116509 | 0.81 | SMN1; SMN2 (0.49) | LMNAHTTSMN1; SMN2ADORA1PTPN1 | |
| SCHEMBL10130727 | 0.79 | GAA (0.69) | LMNASMN1; SMN2GAARAB9AALDH1A1 | |
| SCHEMBL4409751 | 0.78 | LMNA (0.68) | LMNAHTTSMN1; SMN2ADORA1MAPK1 | |
| SCHEMBL14705313 | 0.78 | DEGS1 (0.55) | LMNAHTTMAPK1GAAHPGD | |
| SCHEMBL5654720 | 0.76 | DEGS1 (0.57) | LMNAHTTMAPK1GAAHPGD | |
| SCHEMBL19116658 | 0.76 | RAB9A (0.54) | HTTSMN1; SMN2MAPK1RAB9ANPSR1 | |
| SCHEMBL19116523 | 0.76 | GAA (0.54) | LMNASMN1; SMN2ADORA1PTPN1GAA | |
| SCHEMBL19116877 | 0.76 | NPC1 (0.55) | LMNAHTTSMN1; SMN2PTPN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | disclosed |