Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | TK2 | O00142 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14446905 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1GAACD274PDCD1 | |
| SCHEMBL7830914 | 0.78 | EGLN2 (0.39) | MAPK1HPGDGAAKDM4EEGLN2 | |
| SCHEMBL7834516 | 0.75 | HPGD (0.54) | SMN1; SMN2MAPK1HPGDKDM4EALDH1A1 | |
| SCHEMBL7977989 | 0.73 | CRBN (0.55) | SMN1; SMN2MAPK1GAAKDM4EALDH1A1 | |
| SCHEMBL7833172 | 0.72 | CYP2E1 (0.46) | SMN1; SMN2MAPK1HPGDGAAALDH1A1 | |
| SCHEMBL15688187 | 0.70 | MAPK1 (0.46) | SMN1; SMN2MAPK1HPGDGAAKDM4E | |
| SCHEMBL2026491 | 0.70 | MAPK1 (0.40) | MAPK1HPGDGAAALDH1A1 | |
| SCHEMBL19329297 | 0.69 | POLB (0.49) | SMN1; SMN2MAPK1GAAKDM4EALDH1A1 | |
| SCHEMBL8466158 | 0.69 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1GAACD274PDCD1 | |
| SCHEMBL5166485 | 0.69 | KDM4E (0.56) | SMN1; SMN2HPGDGAACD274PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |