Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17413694 | 0.89 | KDM4E (0.43) | KDM4EGPR3MAPTLMNARAB9A | |
| SCHEMBL17413681 | 0.89 | KDM4E (0.43) | KDM4EGPR3MAPTLMNARAB9A | |
| SCHEMBL5497238 | 0.76 | HTR1A (0.40) | KDM4EHTR1ADRD2ACHEALDH1A1 | |
| SCHEMBL159416 | 0.76 | KDM4E (0.59) | KDM4EGPR3MAPTLMNARAB9A | |
| SCHEMBL31684807 | 0.76 | KDM4E (0.59) | KDM4EGPR3MAPTLMNARAB9A | |
| SCHEMBL7470209 | 0.75 | KDM4E (0.42) | KDM4EGPR3HTR1ADRD2MAPT | |
| Hydrochloric Acid SCHEMBL9110426 | 0.74 | KDM4E (0.57) | KDM4EGPR3MAPTLMNARAB9A | |
| SCHEMBL5493132 | 0.74 | KDM4E (0.44) | KDM4EGPR3MAPTLMNARAB9A | |
| SCHEMBL7893959 | 0.73 | KDM4E (0.43) | KDM4EGPR3MAPTLMNARAB9A | |
| SCHEMBL29780666 | 0.70 | CYP3A4 (0.58) | KDM4EGPR3MAPTLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106565730-A | Method for efficiently synthesizing crinine and analogue thereof through intramolecular dearomatization | 宁波赜军医药科技有限公司 | 2017-04-19 | — | — | CN | disclosed |
| EP-0853624-B1 | PROCESS FOR THE PREPARATION OF GALANTHAMINE AND ITS DERIVATIVES | CHIROTECH TECHNOLOGY LTD (GB) | 2001-02-14 | — | — | EP | disclosed |
| US-6184004-B1 | MIXING CRUSHED DAFFODIL BULBS OR SNOWDROP BULBS WITH AN AMINE OF DEFINED STRUCTURE IN A LIQUID MEDIUM, AND RECOVERING COMPOUND PRODUCED | JANSSEN PHARMACEUTICA, N.V. (BE) | 2001-02-06 | — | — | US | disclosed |
| EP-0853624-A1 | PROCESS FOR THE PREPARATION OF GALANTHAMINE AND ITS DERIVATIVES | CHIROSCIENCE LIMITED (GB) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997011078-A1 | PROCESS FOR THE PREPARATION OF GALANTHAMINE AND ITS DERIVATIVES | CHIROSCIENCE LIMITED (GB) | 1997-03-27 | — | — | WO | disclosed |