Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
| ▸ | TYMS | P04818 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29396047 | 0.81 | KDM4E (0.38) | KDM4EGPR3PIM1HTR1ADRD2 | |
| SCHEMBL28519850 | 0.81 | KDM4E (0.38) | KDM4EGPR3PIM1HTR1ADRD2 | |
| SCHEMBL7833962 | 0.75 | KDM4E (0.47) | KDM4EGPR3PIM1HTR1ADRD2 | |
| SCHEMBL19629535 | 0.73 | KDM4E (0.42) | KDM4EGPR3HTR2CNISCHCYP1A2 | |
| SCHEMBL31668742 | 0.72 | HSD17B10 (0.42) | HTR1ACYP3A4HTR2CNISCHCYP1A2 | |
| SCHEMBL634543 | 0.72 | HSD17B10 (0.42) | HTR1ACYP3A4HTR2CNISCHCYP1A2 | |
| SCHEMBL17413681 | 0.72 | KDM4E (0.43) | KDM4EGPR3CYP3A4NPC1LMNA | |
| SCHEMBL17413694 | 0.72 | KDM4E (0.43) | KDM4EGPR3CYP3A4NPC1LMNA | |
| SCHEMBL159416 | 0.71 | KDM4E (0.59) | KDM4EGPR3CYP3A4NPC1LMNA | |
| SCHEMBL31684807 | 0.71 | KDM4E (0.59) | KDM4EGPR3CYP3A4NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171434-A1 | TETRAHYDROISOQUINOLINYL-INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6245780-B1 | PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORP | 2001-06-12 | — | — | US | disclosed |
| WO-2000064886-A1 | TETRAHYDROISOQUINOLINYL-INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |