Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.49 |
| ▸ | ITGAV | P06756 | 13/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.43 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.43 |
| ▸ | ITGA8 | P53708 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778483 | 0.91 | SUCNR1 (0.53) | SUCNR1ITGB3ITGA2BITGAVITGB6 | |
| SCHEMBL6777032 | 0.91 | ITGB3 (0.50) | SUCNR1ITGB3ITGA2BITGAVTSHR | |
| SCHEMBL7370194 | 0.89 | TSHR (0.58) | SUCNR1ITGB3ITGA2BITGAVTSHR | |
| SCHEMBL240965 | 0.89 | ITGB3 (0.59) | SUCNR1ITGB3ITGA2BITGAVTSHR | |
| SCHEMBL240966 | 0.89 | ITGB3 (0.59) | SUCNR1ITGB3ITGA2BITGAVTSHR | |
| SCHEMBL6777422 | 0.88 | ITGB3 (0.54) | SUCNR1ITGB3ITGA2BITGAVTSHR | |
| SCHEMBL6773593 | 0.88 | SUCNR1 (0.50) | SUCNR1ITGB3ITGA2BITGAVITGB6 | |
| SCHEMBL29391928 | 0.87 | ITGB3 (0.55) | SUCNR1ITGB3ITGA2BITGAVITGB6 | |
| SCHEMBL6780209 | 0.87 | ITGB3 (0.55) | SUCNR1ITGB3ITGA2BITGAVITGB6 | |
| SCHEMBL6772994 | 0.87 | GPR139 (0.52) | SUCNR1ITGB3ITGA2BITGAVITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |