Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GPR132 | Q9UNW8 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 4/20 | 0.47 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.46 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778227 | 0.92 | TSHR (0.58) | NPC1TSHRSMN1; SMN2L3MBTL1GPR132 | |
| SCHEMBL7836171 | 0.91 | TSHR (0.56) | NPC1TSHRSMN1; SMN2L3MBTL1GPR132 | |
| SCHEMBL7340514 | 0.90 | TSHR (0.52) | NPC1MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL7337671 | 0.88 | GPR132 (0.54) | TSHRSMN1; SMN2L3MBTL1GPR132NAMPT | |
| SCHEMBL7370870 | 0.86 | SMN1; SMN2 (0.54) | NPC1KMT2ATSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL7341632 | 0.85 | TSHR (0.49) | NPC1TSHRSMN1; SMN2L3MBTL1GPR132 | |
| SCHEMBL7349960 | 0.84 | GPR132 (0.53) | TSHRSMN1; SMN2L3MBTL1GPR132CMKLR2 | |
| SCHEMBL7834945 | 0.84 | GPR132 (0.52) | TSHRGPR132CMKLR2CMKLR1 | |
| SCHEMBL7347793 | 0.84 | ITGB1 (0.49) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL7341225 | 0.84 | SUCNR1 (0.53) | NPC1MEN1KMT2ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |