SCHEMBL7834331

SCHEMBL7834331

CCNc1nc(Cl)cc(Cl)n1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.60
KMT2A Q03164 2/20 0.47
MAPT P10636 1/20 0.47
GAA P10253 3/20 0.44
POLB P06746 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 2/20 0.42
ALOX15 P16050 1/20 0.42
KDM4E B2RXH2 2/20 0.41
NPC1 O15118 1/20 0.41
NFKB1 P19838 1/20 0.41
CASP3 P42574 1/20 0.41
CDK9 P50750 1/20 0.41
RAB9A P51151 1/20 0.41
CDK5 Q00535 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
CDK5R1 Q15078 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8349356 0.87 KMT2A (0.54) LMNAKMT2AMAPTGAAPOLB
SCHEMBL2772290 0.87 LMNA (0.52) LMNAKMT2AMAPTGAAPOLB
SCHEMBL6106890 0.86 LMNA (0.50) LMNAKMT2AMAPTGAAPOLB
SCHEMBL9381014 0.84 LMNA (0.48) LMNAKMT2AMAPTGAAPOLB
SCHEMBL8345562 0.82 LMNA (0.47) LMNAKMT2AMAPTGAAL3MBTL1
SCHEMBL11586399 0.82 LMNA (0.47) LMNAKMT2AMAPTGAAPOLB
SCHEMBL12963423 0.82 KMT2A (0.50) LMNAKMT2AMAPTGAACYP1A2
SCHEMBL1595678 0.81 KDM4E (0.57) LMNAKMT2AMAPTGAAPOLB
SCHEMBL10811629 0.79 KMT2A (0.49) LMNAKMT2AMAPTL3MBTL1KDM4E
SCHEMBL11652757 0.77 LMNA (0.42) LMNAKMT2AMAPTCYP1A2CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0124810-B1 NEW PYRIMIDINE DERIVATIVES ENDOWED WITH ANTIVIRAL ACTIVITY Gatti, Daniele (IT) 1987-04-01 EP claimed
US-4629729-A Endowed with anti-viral activity 2-alkylamino-4,6-dihalo pyrimidines GATTI DANIELE (IT) 1986-12-16 US claimed
EP-0124810-A1 New pyrimidine derivatives endowed with antiviral activity Gatti, Daniele (IT) 1984-11-14 EP claimed
WO-2004069823-A1 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2004-08-19 WO disclosed
WO-2003024448-A2 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2003-03-27 WO disclosed
EP-0815861-B1 Sulphonamides and their use HOFFMANN LA ROCHE (CH) 2001-09-19 EP disclosed
US-6030976-A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE HOFFMAN-LA ROCHE INC. (US) 2000-02-29 US disclosed
US-5998665-A THERAPY FOR NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-12-07 US disclosed
US-5939451-A INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-08-17 US disclosed
US-5932599-A 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-08-03 US disclosed
EP-0815861-A1 Sulphonamides and their use F. HOFFMANN-LA ROCHE AG (CH) 1998-01-07 EP disclosed
US-4629729-A Endowed with anti-viral activity 2-alkylamino-4,6-dihalo pyrimidines GATTI DANIELE (IT) 1986-12-16 US disclosed
EP-0124810-A1 New pyrimidine derivatives endowed with antiviral activity Gatti, Daniele (IT) 1984-11-14 EP disclosed