Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PGK1 | P00558 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347801 | 0.87 | CYP1A2 (0.50) | LMNAPGK1L3MBTL1BLMCYP1A2 | |
| SCHEMBL12963095 | 0.86 | CYP1A2 (0.47) | PGK1CYP1A2HTTIDH1CYP2C19 | |
| SCHEMBL12932829 | 0.83 | IDH1 (0.41) | CYP1A2HTTIDH1KDM4E | |
| SCHEMBL7834331 | 0.82 | LMNA (0.60) | LMNAPGK1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL12895816 | 0.80 | HTT (0.64) | LMNAL3MBTL1BLMCYP1A2HTT | |
| SCHEMBL12963409 | 0.79 | CYP1A2 (0.47) | LMNAPGK1CYP1A2HTTIDH1 | |
| SCHEMBL10672823 | 0.79 | HTT (0.71) | LMNAL3MBTL1CYP1A2HTTCYP2C19 | |
| SCHEMBL8349356 | 0.76 | KMT2A (0.54) | LMNAL3MBTL1CYP1A2KDM4EGAA | |
| SCHEMBL2772290 | 0.76 | LMNA (0.52) | LMNAL3MBTL1CYP1A2CYP2C19KDM4E | |
| SCHEMBL8834617 | 0.75 | CYP1A2 (0.43) | LMNACYP1A2HTTIDH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |