Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT2 | O75908 | 1/20 | 0.60 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.60 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.58 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.58 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.58 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.58 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.58 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.58 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.58 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.58 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.58 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.58 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.58 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.58 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.58 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.58 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.58 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.58 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.58 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9776434 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL2448622 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL7272103 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL11365418 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL5695284 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL7278374 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL1779858 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL1005094 | 1.00 | SOAT2 (0.60) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL5306363 | 0.98 | CA1 (0.59) | SOAT2SOAT1ENPP2DGAT2PSMB11 | |
| SCHEMBL4133285 | 0.93 | ALDH1A1 (0.58) | SOAT2SOAT1ENPP2DGAT2PSMB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676398-B1 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-1022274-A1 | Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5962470-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5834501-A | TREATING DIABETES OR HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5739345-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1998-04-14 | — | — | US | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |