Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | APAF1 | O14727 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.58 |
| ▸ | ITGAL | P20701 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299882 | 1.00 | ACE (0.62) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8530746 | 1.00 | ACE (0.62) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8556324 | 1.00 | ACE (0.62) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8530732 | 1.00 | ACE (0.62) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8556329 | 1.00 | ACE (0.62) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL6299885 | 1.00 | ACE (0.62) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8157578 | 0.93 | ALOX15 (0.60) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8157574 | 0.93 | ALOX15 (0.60) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8162589 | 0.90 | ECE1 (0.55) | ACEALOX15SMN1; SMN2KDM4EMAPT | |
| SCHEMBL6299926 | 0.90 | ECE1 (0.55) | ACEALOX15SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693489-B1 | Heterocyclic tachykinin receptor antagonist | LILLY CO ELI (US) | 2001-09-12 | — | — | EP | disclosed |
| CN-1067067-C | Heterocyclic tachykinin receptor antagonists | LILLY CO ELI (US) | 2001-06-13 | — | — | CN | disclosed |
| EP-0912178-A4 | METHODS OF TREATING HYPERTENSION | LILLY CO ELI (US) | 2000-08-16 | — | — | EP | disclosed |
| US-6017930-A | Methods of treating or preventing interstitial cystitis | ELI LILLY AND COMPANY (US) | 2000-01-25 | — | — | US | disclosed |
| US-6001837-A | Methods of treating or preventing sleep apnea | ELI LILLY AND COMPANY (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0912178-A1 | METHODS OF TREATING HYPERTENSION | ELI LILLY AND COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0710479-B1 | Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine | LILLY CO ELI (US) | 1999-01-07 | — | — | EP | disclosed |
| US-5846973-A | Methods of treating pulmonary hypertension | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| US-5792760-A | USEFUL IN TREATMENT OF PSYCHOLOGICAL AND CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| US-5744482-A | Serotonin agonist in combination with a tachykinin receptor antagonist in the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1998-04-28 | — | — | US | disclosed |
| EP-0747055-A2 | Use of tachykinin receptors antagonists for the treatment of cold and allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1996029074-A1 | METHODS OF TREATING OR PREVENTING PAIN OR NOCICEPTION | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| EP-0729468-A1 | NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1996024353-A1 | METHODS OF TREATING OR PREVENTING PSYCHIATRIC DISORDERS | ELI LILLY AND COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| EP-0729468-A4 | NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1996-07-12 | — | — | EP | disclosed |
| US-5530009-A | TREATING ASTHMA | ELI LILLY AND COMPANY (US) | 1996-06-25 | — | — | US | disclosed |
| EP-0710479-A1 | Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1996-05-08 | — | — | EP | disclosed |
| WO-1996011000-A1 | METHODS OF TREATING MIGRAINE | ELI LILLY AND COMPANY (US) | 1996-04-18 | — | — | WO | disclosed |
| WO-1996001819-A1 | HETEROCYCLIC TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-01-25 | — | — | WO | disclosed |
| EP-0693489-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |