Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | ACE | P12821 | 4/20 | 0.58 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.54 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.54 |
| ▸ | ITGAL | P20701 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8157578 | 1.00 | ALOX15 (0.60) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL7834723 | 0.93 | ACE (0.62) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL8556329 | 0.93 | ACE (0.62) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL6299885 | 0.93 | ACE (0.62) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL8530746 | 0.93 | ACE (0.62) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL8556324 | 0.93 | ACE (0.62) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL8530732 | 0.93 | ACE (0.62) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL6299882 | 0.93 | ACE (0.62) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL8006586 | 0.85 | ACE (0.52) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL28880633 | 0.84 | KMT2A (0.60) | ALOX15ACEKDM4EAPAF1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994712-A1 | INHIBITORS OF NEUTROPHIL MEDIATED OXIDANT PRODUCTION | ELI LILLY AND COMPANY (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999002163-A1 | INHIBITORS OF NEUTROPHIL MEDIATED OXIDANT PRODUCTION | ELI LILLY AND COMPANY (US) | 1999-01-21 | — | — | WO | disclosed |
| WO-1997007117-A1 | 2-ACYLAMINOPROPANAMINES AS GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |