Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832439 | 0.87 | ALDH1A1 (0.59) | ALDH1A1KDM4EIMPDH2CYP2A6CYP2A13 | |
| SCHEMBL30995729 | 0.80 | ALDH1A1 (0.70) | ALDH1A1KDM4EIMPDH2HSD17B10MAPT | |
| SCHEMBL2275437 | 0.80 | ALDH1A1 (0.70) | ALDH1A1KDM4EIMPDH2HSD17B10MAPT | |
| SCHEMBL1092202 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4EIMPDH2LMNASMN1; SMN2 | |
| SCHEMBL13363658 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4EIMPDH2HPGDHSD17B10 | |
| SCHEMBL1450678 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4EIMPDH2BCHE | |
| SCHEMBL5437254 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4EIMPDH2CYP2A6GSK3B | |
| SCHEMBL1093666 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4EIMPDH2MEN1POLB | |
| SCHEMBL1093582 | 0.74 | ALDH1A1 (0.77) | ALDH1A1KDM4EIMPDH2BCHEMEN1 | |
| SCHEMBL16619395 | 0.73 | ALDH1A1 (0.65) | ALDH1A1KDM4EIMPDH2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680950-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0680950-A1 | PROPENONE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-08 | — | — | EP | disclosed |