Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | FADS1 | O60427 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 4/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6779352 | 0.88 | ITGB3 (0.41) | ITGB3ITGA2BGPR139ITGB1ITGAV | |
| SCHEMBL7346866 | 0.85 | GPR139 (0.41) | KMT2ATP53THRBMEN1ITGB3 | |
| SCHEMBL7823466 | 0.83 | GPR139 (0.40) | TP53THRBITGB3ITGA2BF7 | |
| SCHEMBL7339440 | 0.82 | GPR139 (0.41) | KMT2ATP53THRBMEN1ITGB3 | |
| SCHEMBL6778040 | 0.81 | GPR139 (0.41) | KMT2AMEN1HPGDITGB3ITGA2B | |
| SCHEMBL7341087 | 0.80 | GPR139 (0.48) | KMT2ATHRBMEN1ITGB3F7 | |
| SCHEMBL14450496 | 0.79 | PTGDR2 (0.44) | ITGB3ITGA2BALDH1A1POLB | |
| SCHEMBL7835622 | 0.79 | ITGB3 (0.42) | KMT2AMEN1ITGB3F7GPR139 | |
| SCHEMBL6778730 | 0.77 | ITGB3 (0.40) | KMT2AMEN1ITGB3GPR139ITGB1 | |
| SCHEMBL7341726 | 0.77 | GPR139 (0.42) | KMT2AMEN1ITGB3F7GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |