Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7825727 | 0.91 | TSHR (0.43) | TSHRMMP2MMP9MMP12NPSR1 | |
| SCHEMBL6317736 | 0.89 | NPSR1 (0.49) | TSHRNPSR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7834889 | 0.88 | MAPT (0.49) | TSHRNPSR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7823730 | 0.86 | TSHR (0.43) | TSHRNPSR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7837012 | 0.84 | TSHR (0.47) | TSHRNPSR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7835107 | 0.83 | TSHR (0.46) | TSHRMMP2MMP9MMP12NPSR1 | |
| SCHEMBL7834024 | 0.83 | NPC1 (0.51) | TSHRMMP2MMP9MMP12NPSR1 | |
| SCHEMBL7832805 | 0.82 | TSHR (0.62) | TSHRNPSR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7830099 | 0.82 | ALDH1A1 (0.47) | TSHRNPSR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7832141 | 0.81 | NPSR1 (0.48) | TSHRMMP2MMP9MMP12NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144415-A2 | FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042045-A2 | FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |