Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9772801 | 0.86 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| SCHEMBL6725319 | 0.86 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| SCHEMBL19668660 | 0.82 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| SCHEMBL5306302 | 0.79 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL7306045 | 0.78 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| Nisoxetine SCHEMBL3897550 | 0.77 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| SCHEMBL6729778 | 0.77 | SLC6A9 (0.64) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| Nisoxetine SCHEMBL30026153 | 0.77 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| Nisoxetine SCHEMBL29401038 | 0.77 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 | |
| Nisoxetine SCHEMBL3892886 | 0.77 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |