Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | PGK1 | P00558 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166509 | 0.85 | EHMT2 (0.39) | PDGFRBPDGFRANQO2PGK1ALDH1A1 | |
| SCHEMBL3974493 | 0.84 | PDGFRB (0.47) | PDGFRBPDGFRANQO2PGK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8501335 | 0.80 | PDGFRB (0.43) | PDGFRBPDGFRANQO2PGK1ALDH1A1 | |
| SCHEMBL7835368 | 0.76 | NCF1 (0.59) | NQO2ALDH1A1SMN1; SMN2KDM4EPDE10A | |
| SCHEMBL7837160 | 0.76 | PDE3A (0.47) | PDGFRBPDGFRANQO2PGK1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28426316 | 0.75 | NCF1 (0.57) | NQO2ALDH1A1SMN1; SMN2KDM4EPDE10A | |
| SCHEMBL3970707 | 0.75 | PDGFRB (0.53) | PDGFRBPDGFRANQO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12844007 | 0.74 | ALDH1A1 (0.50) | PDGFRBPDGFRANQO2PGK1ALDH1A1 | |
| SCHEMBL2322922 | 0.73 | ALDH1A1 (0.55) | PDGFRBPDGFRANQO2PGK1ALDH1A1 | |
| SCHEMBL2639183 | 0.73 | PDGFRB (0.52) | PDGFRBPDGFRANQO2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | claimed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | claimed |
| CN-1050187-A | New quinoline compound and preparation method thereof | ICI PLC (GB) | 1991-03-27 | — | — | CN | claimed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | claimed |
| EP-0470795-B2 | Process for the manufacture of nitriles | AVECIA LTD (GB) | 2001-02-21 | — | — | EP | disclosed |
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0470794-B1 | Process for the preparation of nitriles | ZENECA LTD (GB) | 1995-01-25 | — | — | EP | disclosed |
| EP-0470795-B1 | Process for the manufacture of nitriles | ZENECA LTD (GB) | 1995-01-25 | — | — | EP | disclosed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | disclosed |
| EP-0495948-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1992-07-29 | — | — | EP | disclosed |
| CN-1059516-A | The preparation method of biphenylcarbonitriles | ICI LTD (GB) | 1992-03-18 | — | — | CN | disclosed |
| CN-1058965-A | The method for preparing new quinoline | ICI PLC (GB) | 1992-02-26 | — | — | CN | disclosed |
| WO-1992002508-A1 | PROCESS FOR THE MANUFACTURE OF QUINOLINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-20 | — | — | WO | disclosed |
| EP-0470795-A1 | Process for the manufacture of nitriles | ZENECA LIMITED (GB) | 1992-02-12 | — | — | EP | disclosed |
| EP-0470794-A1 | Process for the preparation of nitriles | ZENECA LIMITED (GB) | 1992-02-12 | — | — | EP | disclosed |
| CN-1050187-A | New quinoline compound and preparation method thereof | ICI PLC (GB) | 1991-03-27 | — | — | CN | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |