Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 13/20 | 0.74 |
| ▸ | ABCC8 | Q09428 | 13/20 | 0.74 |
| ▸ | KCNJ11 | Q14654 | 13/20 | 0.74 |
| ▸ | KCNJ8 | Q15842 | 13/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.59 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835453 | 0.91 | ABCC9 (0.67) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6904613 | 0.87 | ABCC9 (0.62) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7234156 | 0.87 | ABCC9 (0.62) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL15450490 | 0.86 | GPR174 (0.70) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7820668 | 0.83 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7836425 | 0.83 | KDM4E (0.68) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7820460 | 0.83 | GPR174 (0.74) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7836312 | 0.83 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL7817258 | 0.82 | GPR174 (0.72) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL3095468 | 0.80 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665834-B1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ASTRAZENECA AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| US-5622964-A | ADMINISTERING 4,6,7,8-TETRAHYDRO-5(1H)-QUINOLONE DERIVATIVE TO TREAT ASTHMA IN MAMMALS | ZENECA LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5455253-A | For urinary incontinence | ZENECA LIMITED (GB) | 1995-10-03 | — | — | US | disclosed |
| EP-0665834-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008966-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1994-04-28 | — | — | WO | disclosed |