SCHEMBL7835866

SCHEMBL7835866

COC(=O)c1cc(CCC(C)=O)cs1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
NPSR1 Q6W5P4 3/20 0.46
DAO P14920 2/20 0.45
ALDH1A1 P00352 4/20 0.43
LMNA P02545 2/20 0.43
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
KDM4E B2RXH2 2/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAOA P21397 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A3 Q01959 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CTPS1 P17812 1/20 0.37
HPGD P15428 4/20 0.36
MAPK1 P28482 2/20 0.36
TSHR P16473 1/20 0.36
ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7832725 0.85 DAO (0.62) MAPTNPSR1DAOALDH1A1LMNA
SCHEMBL9850003 0.83 CYP4A11 (0.49) MAPTNPSR1DAOALDH1A1LMNA
SCHEMBL8226496 0.83 DAO (0.47) MAPTNPSR1DAOALDH1A1NPC1
SCHEMBL6618423 0.82 DAO (0.46) MAPTNPSR1DAOALDH1A1LMNA
SCHEMBL1401554 0.81 NPSR1 (0.46) MAPTNPSR1DAOALDH1A1LMNA
SCHEMBL12468480 0.81 DAO (0.46) MAPTNPSR1DAOCYP1A2SLC6A3
SCHEMBL8180294 0.81 NPSR1 (0.48) MAPTNPSR1DAOALDH1A1LMNA
SCHEMBL9849635 0.81 CYP4A11 (0.53) MAPTNPSR1DAOALDH1A1NPC1
SCHEMBL1401548 0.80 NPSR1 (0.47) MAPTNPSR1DAOALDH1A1LMNA
SCHEMBL1604772 0.79 CYP4A11 (0.54) MAPTNPSR1DAOALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0773943-B1 COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS AGOURON PHARMA (US) 2001-09-26 EP disclosed
US-5646141-A THIENYLALKYLATED DERIVATIVES OF PYRIDO(2,3-D)-PYRIMIDINE, PYRIMIDO(5,4-6)-(1,4)THIAZINE OR PYRIMIDO(5,4-6)-(1,4)SELENAZINE AGOURON PHARMACEUTICALS, INC. (US) 1997-07-08 US disclosed
US-5608082-A GARFT = THE ENZYME GLYCINAMIDE RIBONUCLEOTIDE FORMYL TRANSFERASE AGOURON PHARMACEUTICALS, INC. (US) 1997-03-04 US disclosed