Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849871 | 0.98 | CYP4A11 (0.53) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL9849635 | 0.95 | CYP4A11 (0.53) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL9850003 | 0.89 | CYP4A11 (0.49) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL28342951 | 0.84 | DAO (0.44) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL12468480 | 0.83 | DAO (0.46) | CYP4A11DAOMAPTNPSR1LTB4R | |
| SCHEMBL8226496 | 0.82 | DAO (0.47) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL1401548 | 0.82 | NPSR1 (0.47) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL6618423 | 0.81 | DAO (0.46) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL9849602 | 0.80 | KDM4E (0.40) | CYP4A11CYP4F2DAOMAPTNPSR1 | |
| SCHEMBL8180294 | 0.80 | NPSR1 (0.48) | DAOMAPTNPSR1POLBCTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627332-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051105-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-04-19 | — | — | WO | disclosed |
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-07 | — | — | US | disclosed |
| EP-0415510-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4920125-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, FOLR2, FOLR1 | CYP4A11 783/4885CYP4F2 69/4885DAO 1207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.