Sugi Predict

Sugi Predict / Compounds / SCHEMBL7836617

SCHEMBL7836617

SCHEMBL7836617

Cc1cccc(OC(C(=O)O)C(C)C)c1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.51
▸ PPARG P37231 4/20 0.51
▸ PPARA Q07869 4/20 0.51
▸ ACHE P22303 1/20 0.46
▸ PTGS1 P23219 1/20 0.45
▸ TDP1 Q9NUW8 2/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ GAA P10253 1/20 0.44
▸ TP53 P04637 1/20 0.43
▸ GFER P55789 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ ALOX5 P09917 1/20 0.42
▸ CASP1 P29466 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11714089 0.84 TDP1 (0.44) PPARGPPARATDP1SMN1; SMN2GAA
SCHEMBL8935857 0.83 PPARG (0.62) LMNAPPARGPPARAPTGS1GAA
SCHEMBL17904962 0.83 PPARG (0.62) LMNAPPARGPPARAPTGS1GAA
SCHEMBL8846721 0.83 PPARG (0.62) LMNAPPARGPPARAPTGS1GAA
SCHEMBL14122416 0.83 LMNA (0.49) LMNAACHETDP1SMN1; SMN2GAA
SCHEMBL14121767 0.83 LMNA (0.49) LMNAACHETDP1SMN1; SMN2GAA
SCHEMBL30300697 0.83 LMNA (0.49) LMNAACHETDP1SMN1; SMN2GAA
SCHEMBL14121763 0.83 LMNA (0.49) LMNAACHETDP1SMN1; SMN2GAA
SCHEMBL30300653 0.83 LMNA (0.49) LMNAACHETDP1SMN1; SMN2GAA
SCHEMBL11712221 0.83 LMNA (0.51) LMNAPPARGPPARAPTGS1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117384240-A HIV-1 capsid protein degradation agent based on hydrophobic tag technology and preparation method and application thereof 山东大学 2024-01-12 — — CN disclosed
US-20240009169-A9 PPARG Modulators for the Treatment of Osteoporosis UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2024-01-11 — — US disclosed
US-20230072933-A1 PPARG Modulators for the Treatment of Osteoporosis SCRIPPS RESEARCH INST (US) 2023-03-09 — — US disclosed
US-10744117-B2 PPARG modulators for the treatment of osteoporosis THE SCRIPPS RESEARCH INSTITUTE (US) 2020-08-18 — — US disclosed
US-20180369196-A1 PPARG Modulators for the Treatment of Osteoporosis UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2018-12-27 — — US disclosed
US-10016394-B2 PPARG modulators for treatment of osteoporosis THE SCRIPPS RESEARCH INSTITUTE (US) 2018-07-10 — — US disclosed
US-20170035730-A1 PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2017-02-09 — — US disclosed
WO-2015161108-A1 PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS THE SCRIPPS RESEARCH INSTITUTE (US) 2015-10-22 — — WO disclosed
US-9051265-B2 N-benzylindole modulators of PPARG THE SCRIPPS RESEARCH INSTITUTE (US) 2015-06-09 — — US disclosed
WO-2012170561-A1 N-BENZYLINDOLE MODULATORS OF PPARG THE SCRIPPS RESEARCH INSTITUTE (T.S.R.I.) (US) 2012-12-13 — — WO disclosed
US-5798362-A USEFUL AS ALPHA-ADRENORECEPTOR BLOCKERS; CONDENSATION RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) 1998-08-25 — — US disclosed
US-4155905-A 6-Substituted penicillanic acid and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1979-05-22 — — US disclosed
US-4077967-A 6-Substituted penicillanic acid and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1978-03-07 — — US disclosed
US-4061851-A 7-Amino-7-arylthio cephalosporins E. R. SQUIBB & SONS, INC. (US) 1977-12-06 — — US disclosed
US-4061629-A 6-Amino-6-arylthio penicillanic acids and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1977-12-06 — — US disclosed
US-4056628-A Insecticidal esters of alpha-phenoxy alkanoic acids with substituted benzyl alcohols HOFFMANN-LA ROCHE INC. (US) 1977-11-01 — — US disclosed
US-4029669-A 6-Benzalimino-6-arylthio penicillanic acids and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1977-06-14 — — US disclosed
US-4026886-A 7-Acyl-7-arylthiocephalosporins E. R. SQUIBB & SONS, INC. (US) 1977-05-31 — — US disclosed
US-3965093-A 6-Arylthio penicillanic acid and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1976-06-22 — — US disclosed
US-3954744-A ANTIBACTERIAL E. R. SQUIBB & SONS, INC. (US) 1976-05-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170035730-A1 PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS PPARG, PPARA, PPARD LMNA 2152/4885PPARG 1/4885PPARA 2/4885
US-10016394-B2 PPARG modulators for treatment of osteoporosis PPARG, PPARA, PPARD LMNA 2152/4885PPARG 1/4885PPARA 2/4885
US-20230072933-A1 PPARG Modulators for the Treatment of Osteoporosis PPARG, PPARA, PPARD LMNA 2029/4885PPARG 1/4885PPARA 2/4885
US-20180369196-A1 PPARG Modulators for the Treatment of Osteoporosis PPARG, PPARA, PPARD LMNA 2029/4885PPARG 1/4885PPARA 2/4885
US-10744117-B2 PPARG modulators for the treatment of osteoporosis PPARG, PPARA, PPARD LMNA 2029/4885PPARG 1/4885PPARA 2/4885
US-20240009169-A9 PPARG Modulators for the Treatment of Osteoporosis PPARG, PPARA, PPARD LMNA 2029/4885PPARG 1/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.