Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | HTR6 | P50406 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | BDKRB1 | P46663 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746400 | 0.80 | HTR6 (0.76) | HTR6SMN1; SMN2TDP1MEN1KMT2A | |
| SCHEMBL12259110 | 0.80 | KMT2A (0.77) | GAAHTTSMN1; SMN2TDP1BDKRB1 | |
| SCHEMBL7837239 | 0.79 | HTR6 (1.00) | GAAHTR6HTTSMN1; SMN2TDP1 | |
| SCHEMBL13046884 | 0.78 | MAPK1 (0.61) | HTR6MEN1KMT2AALDH1A1 | |
| SCHEMBL8414789 | 0.77 | HTR6 (0.71) | GAAHTR6MEN1KMT2ALMNA | |
| SCHEMBL14478903 | 0.74 | EP300 (0.71) | GAAHTTSMN1; SMN2BDKRB1MEN1 | |
| SCHEMBL6351422 | 0.74 | HTT (0.67) | GAAHTTSMN1; SMN2BDKRB1MEN1 | |
| SCHEMBL19853016 | 0.74 | TDP1 (0.65) | GAAHTTSMN1; SMN2TDP1BDKRB1 | |
| SCHEMBL12259256 | 0.73 | ALDH1A1 (0.69) | GAAHTTSMN1; SMN2TDP1BDKRB1 | |
| SCHEMBL31668702 | 0.73 | TRPV1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815861-B1 | Sulphonamides and their use | HOFFMANN LA ROCHE (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-6030976-A | SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE | HOFFMAN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998665-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0815861-A1 | Sulphonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-07 | — | — | EP | disclosed |