Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.48 |
| ▸ | ITGAV | P06756 | 10/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.46 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.46 |
| ▸ | ITGA8 | P53708 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838144 | 0.88 | KDR (0.46) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL6778398 | 0.87 | ITGB3 (0.59) | ITGB3ITGAVITGB1ITGA5MDM2 | |
| SCHEMBL7836813 | 0.85 | ITGB3 (0.51) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL7835946 | 0.85 | ITGB3 (0.51) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL6778847 | 0.83 | ITGB3 (0.53) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL6773510 | 0.82 | ITGB3 (0.54) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL240966 | 0.81 | ITGB3 (0.59) | ITGB3ITGAVLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL240965 | 0.81 | ITGB3 (0.59) | ITGB3ITGAVLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL7835706 | 0.81 | ITGB3 (0.50) | ITGB3ITGAVITGB1ITGA5ITGB6 | |
| SCHEMBL6783235 | 0.80 | ITGB3 (0.60) | ITGB3ITGAVLMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |