SCHEMBL7836899

SCHEMBL7836899

CCOc1ccc2cc(C(=O)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)ccc2c1.CCOc1ccc2cc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)ccc2c1

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 9/20 0.37
ACSS2 Q9NR19 2/20 0.35
SIRT2 Q8IXJ6 2/20 0.35
CYP3A4 P08684 8/20 0.35
AKR1C3 P42330 1/20 0.35
AKR1C2 P52895 1/20 0.35
LMNA P02545 1/20 0.34
MAPK1 P28482 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
DGAT1 O75907 2/20 0.33
ADA P00813 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5679939 0.90 CYP17A1 (0.44) CYP17A1ACSS2SIRT2CYP3A4AKR1C3
SCHEMBL5682251 0.88 LMNA (0.42) ACSS2SIRT2AKR1C3AKR1C2LMNA
SCHEMBL5752378 0.84 CYP17A1 (0.43) CYP17A1ACSS2SIRT2CYP3A4ADA
SCHEMBL5750218 0.83 CYP3A4 (0.39) CYP17A1SIRT2CYP3A4SMN1; SMN2
SCHEMBL5750054 0.83 CYP3A4 (0.49) CYP17A1SIRT2CYP3A4MAPT
SCHEMBL4026360 0.83 CYP3A4 (0.42) CYP17A1ACSS2SIRT2CYP3A4
SCHEMBL4024238 0.82 ACSS2 (0.47) CYP17A1ACSS2SIRT2CYP3A4
SCHEMBL1414924 0.82 CYP3A4 (0.52) CYP17A1ACSS2SIRT2CYP3A4
SCHEMBL5752917 0.81 CYP17A1 (0.46) CYP17A1ACSS2SIRT2CYP3A4
SCHEMBL5747757 0.81 CYP3A4 (0.41) CYP17A1SIRT2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1073640-A1 NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 2001-02-07 EP disclosed
WO-1999054309-A1 NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-28 WO disclosed